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Nephrology and Endocrinology

The Department of Nephrology and Endocrinology provides care for kidney diseases, diseases caused by excessive or insufficient hormone actions, endocrine tumors and hypertension, which is closely related to problems with both the kidneys and endocrine system.

Medical services

Board-certified specialists in kidney and endocrine diseases evaluate and treat both outpatients and inpatients. The division also provides outpatient care specializing in hypertension and inpatient programs which include evaluation of and education about hypertension. Each patient referred to us is treated by the same physician to ensure the consistent and appropriate care. We are collaborating with regional clinics, depending on patients’ medical condition.

Diagnosis and treatment policy

The treatment of each patient is discussed during the weekly rounds led by the head of the division and including all full-time assistants and senior attending physicians. In addition, a group of specialists performs detailed assessment of individual cases. For particularly complicated cases, a case review meeting is convened which includes specialists invited from other departments and external institutions.


Kidney failure

Treatment for kidney failure is provided (e.g. hemodialysis for patients with acute and chronic kidney failure; outpatient support services for those receiving home peritoneal dialysis) in cooperation with the Department of Hemodialysis and Apheresis.

Hormone abnormalities

Hormones are produced by various glands, such as the pituitary gland, thyroid gland, parathyroid glands, adrenal glands and gonads, to maintain homeostasis. Abnormal hormone functions manifest themselves in a variety of ways. We perform examinations to identify causes of these abnormalities so as to provide the most appropriate treatment.


We provide the most appropriate treatment for each patient with hypertension to prevent systemic organ dysfunction. Emphasis is also placed on testing and treatment for secondary hypertension caused by adrenal tumors and other diseases.

Target diseases

Acute kidney injury, chronic kidney disease, kidney failure, glomerulonephritis, lgA nephropathy, nephrotic syndrome, electrolyte abnormalities, hypertension, hyperthyroidism, hypothyroidism, hyperparathyroidism, hypoparathyroidism, diabetes insipidus, syndrome of inappropriate secretion of ADH, acromegaly, Cushing’s syndrome, adrenal insufficiency, pheochromocytoma, primary aldosteronism, gonadal failure, disorders of calcium metabolism, osteoporosis, osteomalacia.

Advanced treatments/ Specialized treatments

Home peritoneal dialysis

Peritoneal dialysis can be performed at home. Such patients receive specialist back-up on an outpatient basis.

Diagnosis and treatment for atypical HUS

Frequently performed tests and descriptions

  • Abdominal (kidney) ultrasound examination
  • Thyroid/parathyroid ultrasound examination
  • Thyroid aspiration biopsy
  • Bone densitometry
  • Renal biopsy/endocrine diagnostic tests
  • 24 hour blood pressure monitoring
  • Adrenal venous sampling

Masaomi Nangaku


Division of Nephrology and Endocrinology, Department of Hemodialysis and Apheresis


M.D. , Ph.D.


Chronic kidney disease, Diabetic kidney disease, End stage kidney disease, Hemodialysis, Nephrotic syndrome, Anemia in CKD

Research Interests

Oxygen metabolism of the kidney, immunological kidney injury, epigenetics, renal anemia



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Major diseases and numbers of inpatients treated

[Nephrology] Number of inpatients
1 Hemodialysis and related complications 127
2 Initiation of PD 8
3 Complication of PD 11
4 Kidney transplant and complications after kidney transplantation 20
5 Chronic renal failure 170
6 Acute kidney injury (AKI) 31
7 Nephrotic syndrome 16
8 Chronic glomerulonephritis (CGN) 28
9 Rapidly progressive glomerulonephritis (RPGN) 27
Total number in the Department of Nephrology 443
[Endocrinology] Number of inpatients
1 Primary aldosteronism 38
2 Cushing's syndrome 29
3 Hypopituitarism 25
4 Primary hyperparathyroidism 15
5 Pheochromocytoma and paraganglioma 13
6 Hyperthyroidism 16
7 Diabetes insipidus 10
8 Acromegaly 14
9 Diabetes 16
Total number in the Department of Endocrinology 233


Areas of expertise, treatment and examination methods

  1. Chronic renal disease and failure
  2. Hypertension
  3. Hyperthyroidism
  4. Acute renal failure
  5. Adrenal tumor
  6. Thyroid tumor
  7. Chronic nephritis
Treatment methods
  1. Home peritoneal dialysis
  2. Preventive approaches and educational hospitalization for patients with chronic renal failure
  3. Educational hospitalization for patients with hypertension
  4. Internal radiotherapy for hyperthyroidism
Examination methods
  1. Renal biopsy
  2. Endocrine function test
  3. Thyroid ultrasonography
  4. Adrenal vein sampling
  5. Puncture-aspiration cytodiagnosis

Numbers of major operations and treatments performed in this department

Name of operation/treatment Number
1 Percutaneous transluminal angioplasty(PTA) 47
2 Isotope therapy for Basedow's disease 5
3 Peritoneal dialysis catheter placement 5


Numbers of major and specialized examinations conducted in this department

Name of examination Name of examination
1 Renal biopsy 36
2 Thyroid and parathyroid ultrasonography 946
3 Thyroid aspiration cytodiagnosis 65
4 Adrenal vein sampling 7


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