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Masaomi Nangaku
Departments/Divisions
Division of Nephrology and Endocrinology, Department of Hemodialysis and Apheresis
Titles
M.D. , Ph.D.
Expertise/Specialties
Chronic kidney disease, Diabetic kidney disease, End stage kidney disease, Hemodialysis, Nephrotic syndrome, Anemia in CKD
Research Interests
Oxygen metabolism of the kidney, immunological kidney injury, epigenetics, renal anemia
Languages
Japanese/English
HomePage
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Education
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Year Institution Degree 1988 The University of Tokyo School of Medicine M.D. 1996 The University of Tokyo Graduate School of Medicine Ph.D.
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Training
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Years attended Institution Training 1988-1990 The University of Tokyo Hospital Internship 1990 Showa General Hospital Residency
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Appointments and positions
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Years Institution Title 1990-1991 Tokyo Sailormen’s Hospital 1994-1996 University of Washington Visiting scholar 1997-1998 Tokai University Senior researcher 1998-2012 Division of Nephrology and Endocrinology, Department of Hemodialysis and Apheresis Assistant professor 2012- Division of Nephrology and Endocrinology, Department of Hemodialysis and Apheresis Professor and head
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Board Certifications
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Year Certifications 1991 Board Certification of Japanese Society of Internal Medicine 1999 Board Certification of Japanese Society of Nephrology 2004 Board Certification of Japanese Society for Dialysis Therapy
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Selected Publications
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- Sugahara M, Tanaka S, Tanaka T, Saito H, Ishimoto Y, Wakashima T, Ueda M, Fukui K, Shimizu A, Inagi R, Yamauchi T, Kadowaki T, Nangaku M. Prolyl hydroxylase domain inhibitor protects against metabolic disorders and associated kidney disease in obese type 2 diabetic mice. J Am Soc Nephrol 31, 560-577, 2020
- Hasegawa S, Tanaka T, Saito T, Fukui K, Wakashima T, Susaki EA, Ueda HR, Nangaku M. The oral hypoxia-inducible factor prolyl hydroxylase inhibitor enarodustat counteracts alterations in renal energy metabolism in the early stages of diabetic kidney disease. Kidney Int 97, 934-950, 2020
- Uchida L, Tanaka T, Saito H, Sugahara M, Wakashima T, Fukui K, Nangaku M. Effects of a prolyl hydroxylase inhibitor on kidney and cardiovascular complications in a rat model of chronic kidney disease. Am J Physiol Renal Physiol 318, F388-F401, 2020
- Hirakawa Y, Mizukami K, Yoshihara T, Takahashi I, Khulan P, Honda T, Mimura I, Tanaka T, Tobita S, Nangaku M. Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia. Kidney Int 93, 1483-1489, 2018
- Mimura I, Nangaku M, Kanki Y, Tsutsumi S, Inoue T, Kohro T, Yamamoto S, Fujita T, Shimamura T, Suehiro JI, Taguchi A, Kobayashi M, Tanimura K, Inagaki T, Tanaka T, Hamakubo T, Sakai J, Aburatani H, Kodama T, Wada Y. Dynamic change of the chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of HIF1 and KDM3A. Mol Cell Biol 32, 3018-32, 2012
- Nangaku M. Chronic hypoxia and tubulointerstitial injury. A final common pathway to end stage renal failure. J Am Soc Nephrol 17, 17-25, 2006
- Tanaka T, Miyata T, Inagi R, Fujita T, Nangaku M. Hypoxia in renal disease with proteinuria and/or glomerular hypertension. Am J Pathol 165, 1979-1992, 2004
- Matsumoto M, Makino Y, Tanaka T, Tanaka H, Ishizaka N, Noiri E, Fujita T, Nangaku M. Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J Am Soc Nephrol 14, 1825-32, 2003
- Nangaku M, Sato-Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, Hirokawa N. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 79, 1209-1220, 1994
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Academic Societies
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- International Society of Nephrology (President-Elect)
- Asian Pacific Society of Nephrology (President)
- Japanese Society of Nephrology (Executive Advisor)
- Japanese Society for Dialysis Therapy
- Japanese Society of Internal Medicine (Vice President)
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Editorial Boards
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- Assoicate editor, Kidney International
- American Journal of Physiology Renal Physiology
- Nephrology Dialysis and Transplantation
- American Journal of Nephrology
- Clinical and Experimental Nephrology
- Internal Medicine
- Chinese Medical Journal
- Journal of the American Society of Nephrology (2001-2006)
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Honors
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2015 Academic Award of the Japan Kidney Foundation 2020 Ishibashi Yukiko Memorial Award 2020 Bälz Award
