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Tatsushi Toda

Tatsushi Toda
Departments/Divisions

Neurology, Dementia Center

Titles

M.D., Ph.D.

Expertise/Specialties

Neurology, Neurogenetics

Research Interests

Researches of mono- and polygenic diseases and brain function based on genome analysis (congenital muscular dystrophies, Parkinson’s disease, IQ, mental retardation, etc). Antisense therapy for Fukuyama congenital muscular dystrophy

Languages

Japanese, English

Education
Year Institution Degree
1985 The University of Tokyo School of Medicine M.D.
1993 The University of Tokyo School of Medicine Ph.D.
Training
Years attended Institution Discipline
1985 The University of Tokyo Hospital Internship
1986 Showa General Hospital Resident
Appointments and positions
Years Institution Title
1994-1996 Department of Human Genetics, Graduate School of Medicine, University of Tokyo Assisant Professor
1996-2000 Human Genome Center, Institute of Medical Science, University of Tokyo Associate Professor
2000-2009 Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine Professor
2009- Division of Neurology / Molecular Brain Science, Kobe University Graduate School of Medicine Professor
2011- The Science Council of Japan Member
2017- Department of Neurology, Graduate School of Medicine, University of Tokyo Professor
Board Certifications
Year Certifications
1998 Japanese Board of Medical Genetics and Genomics, Clinical Genetics
2004 Japanese Board of Neurology
Selected Publications
  • Kobayashi K, Nakahori Y, Miyake M, Matsumura K, Kondo-Iida E, Nomura Y, Segawa M, Yoshioka M, Saito K, Osawa M, Hamano K, Sakakihara Y, Nonaka I, Nakagome Y, Kanazawa I, Nakamura Y, Tokunaga K, Toda T. An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature1998; 394:388-392.
  • Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nature Genet.2009; 41:1303-1307.
  • Taniguchi-Ikeda M, Kobayashi K, Kanagawa M, Yu CC, Mori K, Oda T, Kuga A, Kurahashi H, Akman HO, DiMauro S, Kaji R, Yokota T, Takeda S, Toda T. Pathogenic exon-trapping by SVA retrotransposon and rescue in Fukuyama muscular dystrophy. Nature 2011Oct;478:127-131.doi: 10.1038/nature10456.
  • Kanagawa M, Kobayashi K, Tajiri M, Manya H, Kuga A, Yamaguchi Y, Akasaka-Manya K, Furukawa JI, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T. Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy. Cell Rep 2016 Mar 8;14:2209-2223. doi: 10.1016/j.celrep.2016.02.017.
  • Tokuoka H, Imae R, Nakashima H, Manya H, Masuda C, Hoshino S, Kobayashi K, Lefeber DJ, Matsumoto R, Okada T, Endo T, Kanagawa M, Toda T. CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model.　Nat Commun. 2022 Apr 14;13(1):1847. doi: 10.1038/s41467-022-29473-4.
Academic Societies
  • Japanese Society of Neurology, Former President
  • Science Council of Japan, member
  • Doctral program for World-leading Innovative & Smart Education, Japan Society for the Promotion of Science, Director
  • Japan Muscle Society, Vice Chairman
  • The Japan Society of Human Genetics, Director
  • Movement Disorder Society of Japan, Director
  • The Japanese Society of Child Neurology, Director
  • Japan Society for Dementia Research, Coucilor
  • The Japanese Society of Internal Medicine, Councilor
  • Japanese Society for Neuroinfectious Diseases, Coucilor
  • Japanese Society of Neurological Therapeutics
  • American Neurological Associations, Corresponding Fellow
Editorial Boards
  • Journal of Human Genetics, Associate Editor
Honors
1999 Award of Japanese Society of Human Genetics
2001 Award of Japan Foundation for Aging and Health
2002 Award of Societas Neurologica Japonica
2008 Asahi Award
2009 Award from Japanese Minister of Education, Culture, Sports, Science and Technology
2012 Tokizane Memorial Award
2017 Japan Academy Prize
2019 Medical Award of The Japanese Medical Association

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