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Sakae Tanaka

Sakae Tanaka
Departments/Divisions

Orthopaedic Surgery and Spinal Surgery, Medical Support Center

Titles

M.D. , Ph.D.

Expertise/Specialties

Joint surgery, rheumatoid arthritis, osteoporosis

Research Interests

Bone and cartilage biology, arthritis

Languages

Japanese, English

Education
Year Institution Degree
1987 The University of Tokyo School of Medicine M.D.
1996 The University of Tokyo, Graduate School of Medicine Ph.D.
Training
Years attended Institution Training
1987 The University of Tokyo Hospital Internship
1988 Mitsui Memorial Hospital Medica staff
1989-1990 Tokyo Teishin Hospital Medica staff
1993-1995 Yake University School of Medicine Postdoctoral associate
Appointments and positions
Years Institution Title
1996 Department of Orthopaedic Surgery, The University of Tokyo Instructor
2004 Department of Orthopaedic Surgery, The University of Tokyo Assistant Professor
2008 Department of Orthopaedic Surgery, The University of Tokyo Associate Professor
2012 Department of Orthopaedic Surgery, The University of Tokyo Professor
Board Certifications
Year Certifications
1997 Japanese Orthopaedic Association
2002 Japan College of Rheumatology (JCR)-board certified rheumatologist
2007 Japan College of Rheumatology (JCR)-board certified rheumatologist instructor
Selected Publications
  • Tanaka S, Takahashi N, Udagawa N, Tamura T, Akatsu T, Stanley ER, Kurokawa T, Suda T: Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest 1993, 91:257-263
  • Tanaka S, Amling M, Neff L, Peyman A, Uhlmann E, Levy JB, Baron R: c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Nature 1996, 383:528-531
  • Tanaka S, Takahashi N, Nakamura K, Suda,. T. Role of RANKL in physiological and pathological bone resorption and therapeutics targeting RANKL-RANK signaling system. Immunological Review 2005, 108:30-49.
  • Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S. Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast. J Exp Med. 2014 Jan 13;211(1):153-63. doi: 10.1084/jem.20130538. Epub 2013 Dec 23.
Editorial Boards
  • Bone
  • Journal of Bone and Mineral Research
  • Journal of Bone and Mineral Metabolism
  • Journal of Orthopaedic Science
  • Journal of Clinical Investigation
  • Modern Rheumatology
Honors
1992 Young Investigator Award, Japanese Society for Bone and Mineral Research
1993 Young Investigator Award, American Society for Bone and Mineral Research
1997 Young Investigator Award, Japanese Orthopaedic Association
2002 Academic Award, Japanese Society for Bone and Mineral Research
2003 Japan College of Rheumatology Award

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