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Kiyoshi Hasegawa

Kiyoshi Hasegawa
Departments/Divisions

Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division

Titles

M.D., Ph.D., FACS

Expertise/Specialties

Liver transplantation, Hepato-Biliary-Pancreatic Surgery, Hepatocellular carcinoma, Metastatic liver tumor

Research Interests

Surgical treatments for advanced liver malignant tumors, Fluorescence Guided Surgery, Artificial blood vessel

Languages

Japanese / English

HomePage

http://www.u-tokyo-hbp-transplant-surgery.jp/index.html

Education
Year Institution Degree
1993 University of Tokyo Medical School M.D.
2003 The University of Tokyo Graducate School of Medicine Ph.D.
Training
Years attended Institution Training
1993-1994 The University of Tokyo Hospital Resident
1994-1996 Fujieda Municipal Hospital Active Staff & Surgeon
1999-2000 Kanto Medical Center NTT EC Active Staff & Surgeon
Appointments and positions
Years Institution Title
2003-2007 Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine and the University Hospital, the University of Tokyo Assistant Professor
2008-2009 Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine and the University Hospital, the University of Tokyo Lecturer
2009-2017 Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine and the University Hospital, the University of Tokyo Associate Professor
2017-2019 Department of Organ Transplantation, the University of Tokyo Hospital Chairman
2017-present Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine and the University of Tokyo Hospital, the University of Tokyo, Tokyo Professor and Chairman
2019-present Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine and the University of Tokyo Hospital, the University of Tokyo Professor and Chairman
2020-present Organ Transplantation Center, the University of Tokyo Hospital Vice Director
Board Certifications
Year Certifications
1997 Surgeon of the Japan Surgical Society
2002 Gastroenterologist of the Japanese Society of Gastroenterology
2004 Surgeon in Gastroenterology, The Japanese Society of Gastroenterological Surgery
2005 Hepatologist of the Japan Society of Hepatology
2010 Board-certified Instructor (Hepatobiliary-Pancreatic field)
2011 Fellow of the American College of Surgeons
Selected Publications
  • Hasegawa K, Takayama T, Orii R, Sano K, Sugawara Y, Imamura H, Kubota K, Makuuchi M. Effect of hypoventilation on bleeding during hepatic resection: a randomized controlled trial. Arch Surg. 137(3):311-5. 2002.
  • Hasegawa K, Kokudo N, Imamura H, Matsuyama Y, Aoki T, Minagawa M, Sano K, Sugawara Y, Takayama T, Makuuchi M. Prognostic impact of anatomic resection for hepatocellular carcinoma. Ann Surg. 242(2):252-9. 2005.
  • Hasegawa K, Takayama T, Ijichi M, Matsuyama Y, Imamura H, Sano K, Sugawara Y, Kokudo N, Makuuchi M. Uracil-tegafur as an adjuvant for hepatocellular carcinoma: a randomized trial. Hepatology. 44(4):891-5. 2006.
  • Ishizawa T, Hasegawa K, Aoki T, Takahashi M, Inoue Y, Sano K, Imamura H, Sugawara Y, Kokudo N, Makuuchi M. Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma. Gastroenterology. 134(7):1908-16. 2008.
  • Hasegawa K, Kokudo N, Makuuchi M, Izumi N, Ichida T, Kudo M, Ku Y, Sakamoto M, Nakashima O, Matsui O, Matsuyama Y. Comparison of resection and ablation for hepatocellular carcinoma: a cohort study based on a Japanese nationwide survey. J Hepatol. 58(4):724-9. 2013.
  • Hasegawa K, Makuuchi M, Kokudo N, Izumi N, Ichida T, Kudo M, Ku Y, Sakamoto M, Nakashima O, Matsui O, Matsuyama Y; Liver Cancer Study Group of Japan. Impact of histologically confirmed lymph node metastases on patient survival after surgical resection for hepatocellular carcinoma: report of a Japanese nationwide survey. Ann Surg. 259(1):166-70. 2014.
  • Hasegawa K, Aoki T, Ishizawa T, Kaneko J, Sakamoto Y, Sugawara Y, Kokudo N. Comparison of the therapeutic outcomes between surgical resection and percutaneous ablation for small hepatocellular carcinoma. Ann Surg Oncol. 21 Suppl 3:S348-55. 2014.
  • Hasegawa K, Oba M, Kokudo N. Cetuximab for resectable colorectal liver metastasis: new EPOC trial. Lancet Oncol. 15(8):e305-6. 2014.
  • Oba M, Hasegawa K, Shindoh J, Yamashita S, Sakamoto Y, Makuuchi M, Kokudo N. Survival benefit of repeat resection of successive recurrences after the initial hepatic resection for colorectal liver metastases. Surgery. 159(2):632-40. 2016.
  • Ichida A, Hasegawa K, Takayama T, Kudo H, Sakamoto Y, Yamazaki S, Midorikawa Y, Higaki T, Matsuyama Y, Kokudo N. Randomized clinical trial comparing two vessel-sealing devices with crush clamping during liver transection. Br J Surg. 103(13):1795-1803. 2016.
  • Hasegawa K, Saiura A, Takayama T, Miyagawa S, Yamamoto J, Ijichi M, Teruya M, Yoshimi F, Kawasaki S, Koyama H, Oba M, Takahashi M, Mizunuma N, Matsuyama Y, Watanabe T, Makuuchi M, Kokudo N. Adjuvant Oral Uracil-Tegafur with Leucovorin for Colorectal Cancer Liver Metastases: A Randomized Controlled Trial. PLoS One. 11(9):e0162400. 2016.
  • Ho MC, Hasegawa K, Chen XP, Nagano H, Lee YJ, Chau GY, Zhou J, Wang CC, Choi YR, Poon RT, Kokudo N. Surgery for Intermediate and Advanced Hepatocellular Carcinoma: A Consensus Report from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014). Liver Cancer. 5(4):245-256. 2016.
  • Kokudo T, Hasegawa K, Matsuyama Y, Takayama T, Izumi N, Kadoya M, Kudo M, Ku Y, Sakamoto M, Nakashima O, Kaneko S, Kokudo N; Liver Cancer Study Group of Japan. Survival benefit of liver resection for hepatocellular carcinoma associated with portal vein invasion. J Hepatol. 65(5):938-943. 2016.
  • Kokudo T, Hasegawa K, Matsuyama Y, Takayama T, Izumi N, Kadoya M, Kudo M, Kubo S, Sakamoto M, Nakashima O, Kumada T, Kokudo N; Liver Cancer Study Group of Japan. Liver resection for hepatocellular carcinoma associated with hepatic vein invasion: a Japanese nationwide survey. Hepatology. 66(2):510-517.  2017.
  • Shinkawa H, Hasegawa K, Arita J, Akamatsu N, Kaneko J, Sakamoto Y, Kokudo N. Impact of Sustained Virological Response to Interferon Therapy on Recurrence of Hepatitis C Virus-Related Hepatocellular Carcinoma. Ann Surg Oncol. 24(11):3196-3202. 2017.
  • Kawaguchi Y, Sakamoto Y, Ito D, Ito K, Arita J, Akamatsu N, Kaneko J, Hasegawa K, Moriya K, Kokudo N. Statin use is associated with a reduced risk of hepatocellular carcinoma recurrence after initial liver resection. Biosci Trends. 11(5):574-580. 2017.
  • Kawaguchi Y, Hasegawa K, Okura N, Maki H, Akamatsu N, Kaneko J, Arita J, Sakamoto Y, Ohtomo K, Kokudo N. Influence of outflow-obstructed liver volume and venous communication development: A three-dimensional volume study in living donors. Liver Transpl. 23(12):1531-1540. 2017.
  • Kokudo T, Kokudo N, Hasegawa K. Negative phase 3 study of 90Y microspheres versus sorafenib in HCC. Lancet Oncol. 19(2):e68. 2018.
  • Igaki H, Mizumoto M, Okumura T, Hasegawa K, Kokudo N, Sakurai H. A systematic review of publications on charged particle therapy for hepatocellular carcinoma. Int J Clin Oncol. 23(3):423-433. 2018.
  • Shirata C, Hasegawa K, Kokudo T, Yamashita S, Yamamoto S, Arita J, Akamatsu N, Kaneko J, Sakamoto Y, Kokudo N. Liver Resection for Hepatocellular Carcinoma in Patients with Renal Dysfunction. World J Surg. 42(12):4054-4062. 2018.
  • Shimamura T, Akamatsu N, Fujiyoshi M, Kawaguchi A, Morita S, Kawasaki S, Uemoto S, Kokudo N, Hasegawa K, Ohdan H, Egawa H, Furukawa H, Todo S; Japanese Liver Transplantation Society. Expanded living-donor liver transplantation criteria for patients with hepatocellular carcinoma based on the Japanese nationwide survey: the 5-5-500 rule. Transpl Int. 32(4):356-368. 2019.
  • Kokudo T, Hasegawa K, Shirata C, Tanimoto M, Ishizawa T, Kaneko J, Akamatsu N, Arita J, Demartines N, Uldry E, Kokudo N, Halkic N. Assessment of Preoperative Liver Function for Surgical Decision Making in Patients with Hepatocellular Carcinoma. Liver Cancer. 8(6):447-456. 2019.
  • Uranbileg B, Kurano M, Sato M, Ikeda H, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y. Possible involvement of PS-PLA1 and lysophosphatidylserine receptor (LPS1) in hepatocellular carcinoma. Sci Rep. 10(1):2659. 2020.
  • Nakatsuka T, Tateishi K, Kato H, Fujiwara H, Yamamoto K, Kudo Y, Nakagawa H, Tanaka Y, Ijichi H, Ikenoue T, Ishizawa T, Hasegawa K, Tachibana M, Shinkai Y, Koike K. Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis. Cell Death Dis. 12(1):99. 2021.
  • Nakatsuka T, Tateishi K, Kato H, Fujiwara H, Yamamoto K, Kudo Y, Nakagawa H, Tanaka Y, Ijichi H, Ikenoue T, Ishizawa T, Hasegawa K, Tachibana M, Shinkai Y, Koike K. Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis. Cell Death Dis. 12(1):99. 2021.
  • Kawaguchi Y, Hasegawa K, Hagiwara Y, De Bellis M, Famularo S, Panettieri E, Matsuyama Y, Tateishi R, Ichikawa T, Kokudo T, Izumi N, Kubo S, Sakamoto M, Shiina S, Takayama T, Nakashima O, Murakami T, Vauthey JN, Giuliante F, De Carlis L, Romano F, Ruzzenente A, Guglielmi A, Kudo M, Kokudo N. Effect of Diameter and Number of Hepatocellular Carcinomas on Survival After Resection, Transarterial Chemoembolization, and Ablation.Am J Gastroenterol. 116(8):1698-1708. 2021.
Academic Societies
  • Japan Surgical Society
  • The Japanese Society of Gastroenterological Surgery
  • The Japanese Society of Gastroenterology
  • Japanese Society of Hepato-Biliary-Pancreatic Surgery General incorporated association
  • The Japan Society of Hepatology
  • Japan Biliary Association
  • The Japan Society for Transplantation
  • Japanese Liver Trandplantation Society
  • Japan Surgical Association
  • Japan Society of Clinical Oncology
  • The Japanese Pancreas and Islet Transplant Association
  • Japan Liver Cancer Association
  • The Japan NeuroEndocrine Tumor Society
Editorial Boards
  • Surgery Today (Editor-in-Chief)
  • Liver Cancer
  • HPB
  • Japanese Journal of Clinical Oncology
Honors
2007 Young Investigator Award, 17th Asian Pacific Association for the Study of the Liver (APASL)

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