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Hematology and Oncology

The Department of Hematology and Oncology provides medical services for patients with various blood disorders, including anemia and thrombocytopenia, and neoplastic disorders such as leukemia and malignant lymphoma.

Medical services

Outpatient services are available each morning and afternoon on weekdays. The department has a constant inpatient load of approximately 60 patients who receive combined modality therapy including stem cell transplantation in cooperation with the Department of Cell Therapy and Transplantation Medicine.

Diagnosis and treatment policy

With the utmost emphasis placed on providing medical care that satisfies patients, staff and patients discuss treatment together to make it holistic. Individual cases are discussed by the entire staff to select the most effective treatment and achieve advanced medical care.


The department has well-established experience in applying combined modality therapy including chemotherapy and transplantation in treating leukemia, malignant lymphoma, and other malignant tumors.

Target diseases

Almost all hematological diseases including acute leukemia, chronic myelogenous/lymphocytic leukemia, adult T-cell leukemia-lymphoma, polycythemia vera, essential thrombocythemia, primary myelofibrosis, myelodysplastic syndrome, malignant lymphoma, multiple myeloma, aplastic anemia, hemolytic anemia, idiopathic thrombocytopenic purpura, hemophilia.

Advanced treatments/ Specialized treatments

DNA diagnosis of hematopoietic tumors

Based on the latest findings, the department has adopted genetic analysis using the nucleic acid amplification testing (PCR) method with the cooperation of the Department of Clinical Laboratory. The results of various analyses are used for diagnosis, selection of treatment methods and early detection of recurrence of after treatment.

Autologous and allogeneic hematopoietic stem cell transplantation

Hematopoietic stem cell transplantation is a treatment in which hematopoietic stem cell collected from patients themselves or from donors are infused after chemotherapy or radiation therapy. In addition to aiming for a cure through transplantation, the department has established an outpatient follow-up clinic to manage various complications that may occur after transplantation in cooperation with nurses and pharmacists.

Transplantation in elderly recipients

The indications for allogeneic hematopoietic stem cell transplantation in the elderly used to be limited due to side effects and complications, but they are expanding with the advancement in supportive care and non-myeloablative allogeneic stem cell transplant (mini-transplants). The department actively performs allogeneic hematopoietic stem cell transplantation in patients over 65 years old to improve the prognosis of the disease.

State-of-the-art treatment for malignant lymphoma

Treatment methods and drugs for malignant lymphoma have undergone significant updates in recent years and the treatment of CNS lymphoma is one of them. Malignant lymphoma originating from the central nervous system (brain and spinal cord) is known to be refractory to treatment and has a poor prognosis. The department provides a number of treatments, including autologous transplants, to improve the prognosis.

HLA-haploidentical transplant

Conventional hematopoietic stem cell transplants require that the blood types known as HLA match at least 90 percent, and it can be time-consuming to find a match. In recent years, the development of transplant management methods has made it possible to perform transplants from donors whose HLA is half-matched. Called haploidentical transplantations, the department performs this procedure for patients who require it to overcome a disease.

Mineo Kurokawa

Mineo Kurokawa


Department of Hematology and Oncology, Department of Cell Therapy and Transplantation Medicine


M.D. , Ph.D.


Hematological malignancies

Research Interests



Japanese, English

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Major diseases treated in this department and numbers of in- and outpatients

Disease name Number of inpatients Number of outpatients
1 Acute leukemia 43 1,078
2 Chronic myelogenous leukemia 2 873
3 Myelodysplastic syndrome 27 983
4 Malignant lymphoma 172 4,374
5 Multiple myeloma 22 582

Total numbers of patients in 2015

Areas of expertise, treatment and examination methods

  1. Acute leukemia
  2. Malignant lymphoma
  3. Myelodysplastic syndrome
  4. Chronic myeloid leukemia
  5. Multiple myeloma
  6. Aplastic anemia
  7. ITP (idiopathic thrombocytopenic purpura)
  8. Erdheim-Chester disease
Treatment methods
  1. Multi-drug chemotherapy
  2. Allogeneic peripheral blood stem cell transplantation
  3. Allogeneic bone marrow transplantation
  4. Autologous peripheral blood stem cell transplantation
  5. Umbilical cord blood transplantation
  6. Immunosuppressive therapy
  7. Molecular-targeted therapy
  8. Antibody Medicine
Examination methods
  1. Marrow puncture
  2. Lymph node biopsy
  3. Cell surface antigen analysis using flow cytometry (bone marrow and lymph nodes)
  4. Genetic diagnosis (detection and monitoring of genetic abnormalities due to hematologic diseases)
  5. Diagnostic imaging, such as CT and FDG-PET

Numbers of major operations and treatments performed

Name of operation/treatment Number
1 Allogeneic bone marrow transplantation 11
2 Autologous peripheral blood stem cell transplantation 12
3 Umbilical cord blood transplantation 1


Numbers of major and specialized examinations conducted in this department

Name of examination Number
1 Bone marrow examination 800


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