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Yasushi Hirota

Yasushi Hirota
Departments/Divisions

Obstetrics and Gynecology, Perinatal Center

Titles

M.D., Ph.D.

Expertise/Specialties

Obsterics and Gynecology, Reproductive Medicine, Reproductive Surgery

Research Interests

Infertility, Implantation Failure, Preterm Birth, Endometriosis and Adenomyosis

Languages

Japanese / English

HomePage

https://researchmap.jp/yhirota-tky?lang=en

Education
Year Institution Degree
1998 The University of Tokyo School of Medicine M.D.
2005 The University of Tokyo Graduate School of Medicine Ph.D.
Training
Years attended Institution Discipline
1998-99 The University of Tokyo Hospital Residency/Obsteterics and Gynecology
2007-08 Vanderbilt University Research Fellow
2008-10 Cincinnati Childrens Hospital Research Fellow
Appointments and positions
Years Institution Title
2014-20 Department of Obstetrics and Gynecology Assistant Professor
2020-23 Department of Gynecologic Surgery Associte Professor
2023-present Department of Obstetrics and Gynecology Professor
Board Certifications
Year Certifications
2003 Board certified specialist and supervisor, Japan Society of Obstetrics and Gynecology
2012 Board certified specialist and supervisor, Japan Society for Reproductive Medicine
2015 Board certified endoscopist, Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy
2017 Board certified specialist and supervisor, Japan Endocrine Society
Selected Publications
  • Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion. Shun Akaeda, Yasushi Hirota, Yamato Fukui, Shizu Aikawa, Ryoko Shimizu-Hirota, Tetsuaki Kaku, Mona Gebril, Tomoyuki Hirata, Takehiro Hiraoka, Mitsunori Matsuo, Hirofumi Haraguchi, Mayuko Saito-Kanatani, Norihiko Takeda, Tomoyuki Fujii, Yutaka Osuga. EMBO Rep. 22(2) e50927, 2021.
  • Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations. Satoshi Inoue, Yasushi Hirota, Toshihide Ueno, Yamato Fukui, Emiko Yoshida, Takuo Hayashi, Shinya Kojima, Reina Takeyama, Taiki Hashimoto, Tohru Kiyono, Masako Ikemura, Ayumi Taguchi, Tomoki Tanaka, Yosuke Tanaka, Seiji Sakata, Kengo Takeuchi, Ayako Muraoka, Satoko Osuka, Tsuyoshi Saito, Katsutoshi Oda, Yutaka Osuga, Yasuhisa Terao, Masahito Kawazu, Hiroyuki Mano. Nat. Commun. 10(1) 5785-5785, 2019.
  • HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment. Leona Matsumoto, Yasushi Hirota, Tomoko Saito-Fujita, Norihiko Takeda, Tomoki Tanaka, Takehiro Hiraoka, Shun Akaeda, Hidetoshi Fujita, Ryoko Shimizu-Hirota, Shota Igaue, Mitsunori Matsuo, Hirofumi Haraguchi, Mayuko Saito-Kanatani, Tomoyuki Fujii, Yutaka Osuga. J. Clin. Invest. 128(7) 3186-3197, 2018.
  • p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. Wenbo Deng, Jeeyeon Cha, Jia Yuan, Hirofumi Haraguchi, Amanda Bartos, Emma Leishman, Benoit Viollet, Heather B. Bradshaw, Yasushi Hirota, Sudhansu K. Dey. J. Clin. Invest. 126(8), 2941-2954, 2016.
  • Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions. Jeeyeon Cha, Amanda Bartos, Mahiro Egashira, Hirofumi Haraguchi, Tomoko Saito-Fujita, Emma Leishman, Heather Bradshaw, Sudhansu K. Dey, Yasushi Hirota. J. Clin. Invest. 123(9) 4063-4075, 2013.
Academic Societies
  • Japan Society of Obstetrics and Gynecology
  • Japan Society for Reproductive Medicine
  • Japan Endocrine Society
  • Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy
  • Japan Endometriosis Society
  • Japan Society of Perinatal and Neonatal Medicine
  • Molecular Biology Society of Japan
  • Japanese Society of Inflammation and Regeneration
  • Japanese Society of Anti-aging Medicine
Editorial Boards
  • Scientific Reports (2022-present)
  • Molecular Human Reproduction (2011-2015)
Honors
2022 Kanzawa Medical Research Foundation Medical Award
2017 Japan Medical Association Medical Research Encouragement Prize
2017 The Japan Endocrine Society Research Award
2013 The Japanese Society of Inflammation and Regeneration Research Award
2009 Japan Society of Obstetrics and Gynecology Research Award
2007 Japan Society for Reproductive Medicine Research Award

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