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Toshimasa Yamauchi

Toshimasa Yamauchi
Departments/Divisions

Department of Diabetes and Metabolic Diseases

Titles

M.D. , Ph.D.

Expertise/Specialties

Internal Medicine, Diabetes, Metabolism, Nutrition, Obesity, Metabolic Syndrome, Diabetic Complications, Atherosclerosis, Insulin Resistance, Adipokines, Nuclear Receptors, Epigenetics, GWAS, Sportology, Anti-Aging Medicine

Research Interests

The mechanisms by which obesity results in insulin resistance, atherosclerosis and short life

Languages

Japanese / English

Education
Year Institution Degree
1992 The University of Tokyo School of Medicine M.D.
1998 The University of Tokyo Graducate School of Medicine Ph.D.
Training
Years attended Institution Training
1992-1993 The University of Tokyo Hospital Residency/Internal Medicine
1993-1994 Tokyo Kouseinenkin Hospital Residency/Internal Medicine
1994-1998 The University of Tokyo Hospital Clinical Research Fellowship/Internal Medicine
1998-2003 The University of Tokyo Hospital Post-Doctoral Fellowship/Internal Medicine
Appointments and positions
Years Institution Title
2003-2004 Department of Diabetes and Metabolic Diseases, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo Assitant Professor
2004-2010 Department of Integrated Molecular Science on Metabolic Diseases, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo Associate Professor
2008-present Sportology Center, Graduate School of Medicine, Juntendo University Visiting Professor
2010-2014 Department of Diabetes and Metabolic Diseases, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo Lecturer
2014-present Department of Diabetes and Metabolic Diseases, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo Associate Professor and Chairman
Board Certifications
Year Certifications
2003 Fellow of the Japanese Society of Internal Medicine (FJSIM)
2001 Board Certified Diabetologist
1996 Board Certified Member of the Japanese Society of Internal Medicine
Selected Publications
  • Okada-Iwabu, M., Yamauchi, T., et al. : A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503: 493-499, 2013
  • Yamauchi T, Kadowaki T. Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. Cell Metab. 17:185-196, 2013.
  • Yamauchi, T., et al. : A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics 42: 864-868, 2010
  • Iwabu, M., Yamauchi, T., et al. : Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 464:1313-1319, 2010
  • Yamauchi T, et al. : Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 13: 332 - 339, 2007
  • Yamauchi, T., et al. : Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-769, 2003
  • Yamauchi, T., et al. : Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 8:1288-1295, 2002.
  • Yamauchi, T., et al. : Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nature Genetics 30:221-226, 2002
  • Yamauchi, T., et al. : The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 7:941-946, 2001
Academic Societies
  • The Japanese Society of Internal Medicine (Councilor)
  • The Japan Diabetes Society (Secretary General, Councilor)
  • The Japan Endocrine Society (Councilor)
  • The Japanese Society of Molecular Medicine (Councilor)
  • The Japan Society for the Study of Obesity (Councilor)
  • Japanese Society for Treatment of Obesity (Councilor)
  • Japan Society of Metabolism and Clinical Nutrition (Councilor)
  • The Japan Society of Diabetic Complications
  • The Japanese Society of Anti-Aging Medicine
  • Assistant Editorial Board of Journal of Diabetes Investigation (JDI)
  • Assistant Editorial Board of Obesity Research & Clinical Practice (ORCP)
Honors
1999 Science Prize
2001 Young Investigator's Award of the Japanese Society of Molecular Medicine
2001 Erwin von Baelzprize
2001 Research Award of the Study Group of Molecular Diabetology
2002 Young Investigator Award of the Japan Endocrine Society
2003 Young Investigator Award of the Japan Society of Diabetic Complications
2003 Young Investigator Award of the Japan Society for the Study of Obesity
2004 Research Award of the Tokyo Medical Association
2005 Research Award of the Fellows' Association of The Japanese Society of Internal
Medicine
2005 Research Award of the Japan Society for the Study of Obesity
2006 Lilly Award of the Japan Diabetes Society
2006 Research Support Award of the Japan Medical Association
2007 Young Investigator's Award of the Japanese Society of Internal Medicine
2007 Research Award of the Japan Endocrine Society
2008 Research Award of the Japanese Society of Molecular Medicine
2009 Irvine H. Page Young Investigator Research Award (ATVB) Finalist
2009 Research Award of the Japanese Society of Constitutional Medicine
2011 JSPS (Japan Society for the Promotion of Science) PRIZE
2011 Yomiuri Gold Medal
2014 Outstanding Scientific Achievement Award of the Japan Society of Experimental Diabetes and Obesity

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