医局員紹介(近藤 健二)

IMG_0406近藤健二 

准教授
平成6年入局
東京大学卒

 

 

 

 

 

 

略歴

1994年東京大学医学部医学科卒業。東京大学医学部附属病院耳鼻咽喉科、亀田総合病院耳鼻咽喉科で研修。
2001年東京大学大学院医学系研究科(耳鼻咽喉科学)修了。2001年より東京大学医学部附属病院耳鼻咽喉科助手。 2004年~2005年米国カリフォルニア大学サンディエゴ校耳鼻咽喉科博士研究員。
2006年4月より医局長。2008年5月より講師。
2016年6月より現職。

専門

鼻科学、嗅覚医学、顔面神経疾患を専門とする。手術は内視鏡下鼻副鼻腔手術のほか耳、鼻、咽頭および頚部の疾患を担当している。 また加齢による嗅覚障害の病態生理の解明と治療法の開発、内耳神経の発生、再生機構の研究など、 基礎医学の成果を感覚器の臨床医学に応用すべく研究を行っている。

所属学会

1.日本耳鼻咽喉科学会 (学術委員、専門医)
2.日本鼻科学会(学会誌編集委員)
3.日本耳鼻咽喉科免疫アレルギー学会
4.日本顔面神経学会 
5.日本耳科学会
6.日本頭頸部外科学会
7.  日本味と匂学会
8.  Association for Research in Otolaryngology Active Member 

主な論文

顔面神経疾患

Kondo K, Takeuchi N, Tojima H, Ito K, Yamasoba T: Reconstruction of the intratemporal facial nerve using interposition nerve graft: time course of recovery in facial movement and electrophysiological findings. Acta Otolaryngol 127: supplement 559, 85-90, 2007.

Ushio M, Kondo K, Takeuchi N, Tojima H, Yamaguchi T, Kaga K: Prediction of the prognosis of Bell’s palsy using multivariate analyses. Otol Neurotol 29 :69-72, 2008.

Takanami T, Kondo K, Asakage T: Facial paralysis after superselective intraarterial chemotherapy via the middle meningeal artery in maxillary cancer. Auris Nasus Larynx 36: 479-81, 2009

Kanaya K, Ushio M, Kondo K, Hagisawa M, Suzukawa K, Yamaguchi T, Tojima H, Suzuki M, Yamasoba T: Recovery of facial movement and facial synkinesis in Bell’s palsy patients. Otol Neurootol 30: 640-644, 2009

Baba S, Kondo K, Kanaya K, Ushio M, Tojima H, Yamasoba T: Bell’s palsy in children: relationship between electroneurography findings and prognosis in comparison with adults. Otol Neurotol 32: 1554-8, 2011

Iwamura H, Kondo K, Sawamura H, Baba S, Yasuhara K, Yamasoba T: Amblyopia Associated with Congenital Facial Nerve Paralysis. ORL J Otorhinolaryngol Relat Spec 78:105-10, 2016

嗅覚

Watanabe K, Kondo K, Takeuchi N, Nibu K, Kaga K: Age-related changes in cell density and the proliferation rate of olfactory ensheathing cells in the lamina propria of postnatal mouse olfactory mucosa. Brain Res 1116: 82-92, 2006

Kondo K, Watanabe K, Sakamoto T, Suzukawa K, Nibu K, Kaga K, Yamasoba T: Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman’s glands in mouse olfactory mucosa: age-related progression. Cell Tissue Res 335:489-503, 2009

Kondo K, Suzukawa K, Sakamoto T, Watanabe K, Kanaya K, Ushio M, Yamaguchi T, Nibu K, Kaga K, Yamasoba T: Age-related changes in cell dynamics of the postnatal mouse olfactory neuroepithelium: cell proliferation, neuronal differentiation and cell death. J Comp Neurol 518: 1962-1975, 2010

Suzukawa K, Kondo K, Kanaya K, Sakamoto T, Watanabe K, Ushio M, Kaga K, Yamasoba T: Age-related changes of the regeneration mode in the mouse peripheral olfactory system following olfactotoxic drug methimazole-induced damage. J Comp Neurol 519: 2154-74, 2011

Kanaya K, Kondo K, Suzukawa K, Sakamoto T, Kikuta S, Okada K, Yamasoba T: Innate immune responses and neuroepithelial degeneration and regeneration in the mouse olfactory mucosa induced by intranasal administration of Poly(I:C). Cell Tissue Res 357:279-99, 2014

Baba M, Itaka K, Kondo K, Yamasoba T, Kataoka K: Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles. J Control Release 201:41-8, 2014

Kikuta S, Sakamoto T, Nagayama S, Kanaya K, Kinoshita M, Kondo K, Tsunoda K, Mori K, Yamasoba T: Sensory deprivation disrupts homeostatic regeneration of newly generated olfactory sensory neurons after injury in adult mice. J Neurosci 35:2657-73, 2015

Ueha R, Ueha S, Kondo K, Sakamoto T, Kikuta S, Kanaya K, Nishijima H, Matsushima K, Yamasoba T: Damage to Olfactory Progenitor Cells Is Involved in Cigarette Smoke-Induced Olfactory Dysfunction in Mice. Am J Pathol 186:579-86, 2016

副鼻腔炎・アレルギー

Baba S, Kondo K, Kanaya K, Suzukawa K, Sato T, Kurata H, Hiruma T, Fujita H, Yahagi N, Yamasoba T: Tsunami sinusitis. Lancet 378: 1116, 2011

Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, Nambu A, Kondo K, Suto H, Saito H, Matsumoto K, Yamasoba T, Nakae S: IL-33, but Not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis. PLoS ONE. 2013;8:e78099.doi:10.1371

Baba S, Kondo K, Kanaya K, Suzukawa K, Ushio M, Urata S, Asakage T, Kakigi A, Suzukawa M, Ohta K, Yamasoba T: Expression of IL-33 and its receptor ST2 in chronic rhinosinusitis with nasal polyps. Laryngoscope 124: 115-22, 2014

Yoshihara S, Kondo K, Kanaya K, Suzukawa K, Baba S, Toma-Hirano M, Kikuta S, Iwasaki Y, Fujio K, Yamasoba T: Tumour necrosis factor inhibitor-associated sinusitis. Rhinology 52:246-51, 2014

Baba S, Kondo K, Toma-Hirano M, Kanaya K, Suzukawa K, Ushio M, Suzukawa M, Ohta K, Yamasoba T: Local increase in IgE and class switch recombination to IgE in nasal polyps in chronic rhinosinusitis. Clin Exp Allergy 44:701-12, 2014

Kagoya R, Kondo K, Baba S, Toma-Hirano M, Nishijima H, Suzukawa K, Kikuta S, Yamasoba T: Correlation of basophil infiltration in nasal polyps with the severity of chronic rhinosinusitis. Ann Allergy Asthma Immunol 114:30-5, 2015

Suzuki S, Yasunaga H, Matsui H, Fushimi K, Kondo K, Yamasoba T: Complication rates after functional endoscopic sinus surgery: analysis of 50,734 Japanese patients. Laryngoscope 125:1785-91, 2015

Baba S, Kagoya R, Kondo K, Suzukawa M, Ohta K, Yamasoba T: T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients. Allergy Asthma Clin Immunol Nov 19;11:33. eCollection, 2015

内耳基礎

Kondo K, Sagara H, Hirosawa K, Kaga K, Matsushima S, Mabuchi K, Uchimura H, Watanabe T: Hair cell development in vivo and in vitro: analysis by using a monoclonal antibody specific to hair cells in the chick inner ear. J Comp Neurol 445: 176-198, 2002

Yamasoba T, Kondo K: Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo. Cell Tissue Res 325: 23-31, 2006

Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA: Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci USA 106: 19432-7, 2009

Jin Y, Kondo K, Ushio M, Kaga K, Ryan AF, Yamasoba T: Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology. Cell Tissue Res 351: 15-27, 2013

Kondo K, Pak K, Chavez E, Mullen L, Euteneuer S, Ryan AF: Changes in responsiveness of rat spiral ganglion neurons to neurotrophins across age: differential regulation of survival and neuritogenesis. Int J Neurosci. 123:465-475, 2013

 

Curriculum Vitae