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Takashi Kadowaki

Takashi Kadowaki
Departments/Divisions

Department of Diabetes and Metabolic Diseases

Titles

M.D., Ph.D.

Expertise/Specialties

Diabetes, Metabolism, Obesity, Nutrition,

Research Interests

Pathogenesis of type2 diabetes, insulin resistance, adiponectin

Languages

Japanese / English

HomePage

http://dm301k.umin.jp/

Education
Year Institution Degree
1978 The University of Tokyo School of Medicine M.D.
1997 The University of Tokyo Graduate School of Medicine Ph.D.
Training
Years attended Institution Training
1978-1980 Tokyo University Medical School Resident in Internal Medicine
1980-1986 The Third Department of Internal Medicine, Faculty of Medicine,The University of Tokyo
(Section Chief: Dr. Masato Kasuga)
Clinical Research Fellow, Diabetes Section
1986-1990 National Institute of Diabetes, Digestive, and Kidney, Disease, National Institutes of Health, Bethesda, MD, U.S.A. (Branch Chief: Dr. Simeon Taylor) Visiting Fellow, Biochemistry and Molecular Pathophysiology Section, Diabetes Branch
Appointments and positions
Years Institution Title
1990-1998 the Third Department of Internal Medicine, Faculty of Medicine, The University of Tokyo Chief, Diabetes Branch, Assistant Professor
1998-2000 the Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo Chief, Diabetes Branch, Lecturer
2001-2003 the Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo Chief, Diabetes Branch, Associate Professor
2003-present the Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo Professor and Chairman
2004-2006 The University of Tokyo Advisor to the President
2005-2010 The University of Tokyo Hospital Vice-director
2008-present The Japan Diabetes Society Chairman of the Board of Directors
2011-present The University of Tokyo Hospital Director
2012-present The University of Tokyo Head of Translational Research Initiative
Board Certifications
Year Certifications
Medical liscence (No.242696)
Ph.D. in Medicine (The University of Tokyo No.13574)
Board certified specialist of Japanese Society of Internal Medicine(No. 4373)
Board certified specialist (No. 1421) and educator (No. 355) of Japan Diabetes Society
Selected Publications
  • Kadowaki T, Bevins CL, Cama A, Ojamaa K, Marcus-Samuels B, Kadowaki H, Beitz L, McKeon C, Taylor SI: Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance. Science 240: 787-790, 1988
  • Kadowaki T, Kadowaki H, Mori Y, Tobe K, Sakuta R, Suzuki Y, Tanabe Y, Sakura H, Awata T, Goto Y, Hayakawa T, Matsuoka K, Kawamori R, Kamada T, Horai S, Nonaka I, Hagura R, Akanuma Y, Yazaki Y: A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. N. Engl. J. Med. 330: 962-968, 1994
  • Tamemoto H, Kadowaki T*, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S: Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372: 182-186, 1994
    (* corresponding author)
  • Kadowaki T: Insights into insulin resistance and type 2 diabetes from knockout mouse models.
    J. Clin. Invest. 106: 459-465, 2000
  • Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T: The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 7:941-946, 2001
  • Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423: 762-769, 2003
  • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes and metabolic syndrome-Adiponectin hypothesis-.
    J.Clin.Invest. 116: 1784-1792, 2006
  • Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T: Adiponectin and AdipoR1 regulate PGC1α and mitochondria by Ca2+ and AMPK/SIRT1. Nature 464: 1313-1319, 2010
  • Yamauchi T, Kadowaki T: Adiponectin receptor as a key player in healthy longevity and obesity-related diseases.
    Cell Metab. 17:185-196, 2013
  • Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T: Small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503: 493-499, 2013
Academic Societies
  • The Japan Diabetes Society (Chairman of the Board of Directors)
  • The Japan Endocrine Society (Board Member)
  • Japan Society for the Study of Obesity (Board Member)
  • American Diabetes Association
  • The Endocrine Society
  • Asian Association for the Study of Diabetes
Editorial Boards
  • Endocrine J. (Editorial Board, 1990-1999)
  • Diabetologia (Associate Editor, 2000-2002)
  • Diabetes (Editorial Board, 2002-)
  • J. Clin. Invest. (Editorial Board, 2002-2012)
  • Metabolic Syndrome and Related Disorders (Editorial Board, 2002-)
  • The Journal of Endocrine Genetics (Editorial Board, 2003-)
  • Diabetes, Obesity and Metabolism (Editorial Board, 2004-)
  • Current Diabetes Reviews (Editorial Board, 2004-)
  • Arteriosclerosis Thrombosis and Vascular Biology (Editorial Board, 2004-2007)
  • Endocrinology (Editorial Board, 2004-2007)
  • Diabetes Care (Editorial Board, 2007-)
  • The Journal of Clinical Endocrinology & Metabolism (Editorial Board, 2007-)
  • Best Practice & Research Clinical Endocrinology & Metabolism (Editorial Board, 2007-)
  • Journal of Diabetes (Editorial Board, 2009-)
  • Journal of Diabetes Investigation (Executive Editor, 2010-)
  • Diabetology International (Editorial Board Member, 2010-)
  • Cell Metabolism (Editorial Board, 2012-)
  • Molecular Metabolism (Regional Editor for Asia, 2012-)
Honors
1986-1990 Fogarty International Fellowship
1992 Young Investigator Award of the Japanese Society of Internal Medicine
1993 Research Award of the Japan Endocrine Society
1993 Shionogi-Lilly Award of the Japan Diabetes Society
1993 Research Support Award of the Japan Medical Association
1995 Research Award of the Tokyo Medical Association
1995 Research Award of the Association of Tokyo University Medical School
2001 Erwin von Baelzprize
2001 The Best Teacher's Award of Tokyo University Medical School
2002 Academic Award of the Mochida Memorial Foundation
2004 Hagedorn Award of the Japan Diabetes Society
2004 Sankyo Takamine Memorial Award
2007 Medical Award of The Japan Medical Association
2007 The Uehara Prize
2008 Award of the Japan Society of Experimental Diabetes and Obesity
2010 Awardee of a Medal with Purple Ribbon
2011 Takeda Medical Science Prize
2012 Japan Endocrine Society Award
2012 Kroc Lecture in Diabetes, University of Chicago
2013 Japan Society of Diabetic Complications Expert Investigator Award
2013 Japan Society for the Study of Obesity Award
2013 Japan Academy Prize

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