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Kazuhiko Yamamoto

Kazuhiko Yamamoto
Departments/Divisions

Allergy and Rheumatology

Titles

M.D. , Ph.D.

Expertise/Specialties

Rheumatology, internal Medicine and immunolog

Research Interests

Dr. Yamamoto’s research interests include T cell receptor gene transfer for controlling autoimmune disorders, characterization of newly identified regulatory T cells and genetic analyses of rheumatoid arthritis and other autoimmune diseases.

Languages

Japanese, English

HomePage

http://ryumachi.umin.jp/index.html

Education
Year Institution Degree
1977 The University of Tokyo School of Medicine M.D.
Training
Years attended Institution Training
4 Graduate School of Medicine, The University of Tokyo Department of Allergy and Rheumatology
1 Yamanashi Prefectural Central Hospital Internal Medicine
Appointments and positions
Years Institution Title
2007 - present International Research Center for Medical Education,The University of Tokyo Director
1997 - present Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo Professor of Medicine, Chairman
1995 - 1997 Department of Clinical Immunology,Medical Institute of Biorogulation, Kyushu University Professor of Medicine
1993 - 1995 Institute of Medicine Science, St. Marianna University, School of Medicine Associate Professor
1991 - 1993 Department of Medicine and Physical Therapy,School of Medicine, The University of Tokyo Assistant Professor
1985 - 1991 Department of Medicine and Physical Therapy,School of Medicine, The University of Tokyo Clinical and Research Fellow
1982 - 1985 Institute of Immunology and Genetics, German Cancer Research Center, Heidelberg Guest Researcher
1979 - 1982 Department of Medicine and Physical Therapy and Research Fellow, Department of Immunology, School of Medicine, The University of Tokyo Clinical and Research Fellow
1977 - 1979 The University of Tokyo Hospital and Central Hospital of Yamanashi Prefecture Resident of Internal Medicine
Board Certifications
Year Certifications
Japan College of Rheumatology
The Japanese Society of Internal Medicine
Selected Publications
  • Okada Y, et al (+92人), Yamamoto K. and Plenge RM. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2014;506(7488):376-381.
  • Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet. 2012;44:511-6.
  • Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci USA.2009:106:13974-79.
  • Yamamoto K, Yamada R. Lessons from a Genomewide Association Study of Rheumatoid Arthritis. N.Engl.J.Med. 2007;357:1250-1251.
  • Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae SC, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet. 2005;37:478-485.
  • Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, Ohtsuki M, Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003;34:395-402.
  • Kohsaka H, Yamamato K, Fujii H, Miura H, Miyasaka N, Nishioka K and Miyamoto T. Fine epitope mapping of the human SS-B/La protein:identification of a distinct autoepitope homologous to a viral gag polyprotein. J Clin Invest. 1990;85:1566-1574.
Academic Societies
  • The Japanese Society of Internal Medicine
  • Japan College of Rheumatology
  • The Japan Society for Clinical Immunology
  • The Japanese Society for Clinical Rheumatology and Related Research
  • Japanese Society for Immunology
  • Japanese Society of Allergology
  • The Japanese Society of Inflammation and Regeneration
  • Japanease Society of Moleculer Medicine
  • The Tokyo Society of Medical Sciences
Editorial Boards
  • Nature Reviews Rheumatology
  • Annals of the Rheumatic Diseases
  • Arthritis Research & Therapy
  • Current Opinion in Rheumatology
  • International Immunology
Honors
1993 Japan College of Rheumatology-Prize
1994 CIBA-GEIGY Rheumatism-Prize
2012 Baelz-Preis

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