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Kazuhiko Koike

Kazuhiko Koike
Departments/Divisions

Department of Gastroenterology

Titles

M.D. , Ph.D.

Expertise/Specialties

Gastroenterology, Hepatology (Hepatitis, Hepatocellular Carcinoma), Pancreatology

Research Interests

Viral hepatitis, Hepatocarcinogenesis, NASH, Oxidative stress

Languages

Japanese / English

HomePage

http://gastro.m.u-tokyo.ac.jp/med/home.html

Education
Year Institution Degree
1980 The University of Tokyo, Faculty of Medicine M.D.
Training
Years attended Institution Training
1980-1984 The University of Tokyo Hospital Internal medicine, Hepatology
1984-1985 National Institute of Health, Japan Molecular Virology
1986-1989 National Cancer Institute, NIH, Bethesda, MD, USA Molecular Virology
1989-1998 The University of Tokyo Hepatology, Gastroenterology
Appointments and positions
Years Institution Title
1991-1997 First Department of Internal Medicine, The University of Tokyo Assistant Professor
1997-1998 First Department of Internal Medicine, The University of Tokyo Lecturer
1998-2004 Department of Infectious Diseases, The University of Tokyo Associate Professor
2004-2009 Department of Infectious Diseases, The University of Tokyo Professor & Chairperson
2009- Department of Gastroenterology,The University of Tokyo Professor & Chairperson
Board Certifications
Year Certifications
Internal Medicine
Hepatology
Gastroenterology
Selected Publications
  • He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling. Cell 2013;155(2):384-396.
  • Kojima K, Takata A, Vadnais C, Otsuka M, Yoshikawa T, Akanuma M, Kondo Y, Kang YJ, Kishikawa T, Kato N, Xie Z, Zhang WJ, Yoshida H, Omata M, Nepveu A, Koike K. MicroRNA122 is a key regulator of α-fetoprotein expression and biologically aggressive behavior of hepatocellular carcinoma. Nat Commun 2011 Jun 7;2:338.
  • Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Matsuura Y, Kimura S, Miyamura T, Koike K. Hepatitis C virus core protein induces hepatocellular carcinoma in transgenic mice. Nat Med 4:1065-1068,1998.
  • Koike K, Moriya K, Yotsuyanagi H, Shintani Y, Fujie H, Ishibashi K, Matsuura Y, Kurokawa K, Miyamura T. Sialadenitis resembling Sjögren's syndrome in mice transgenic for hepatitis C virus envelope genes. Proc Natl Acad Sci USA 94:233-236,1997.
Academic Societies
  • Director General, The Japanese Society of Internal Medicine
  • Director General, The Japan Society of Hepatology (JSH)
  • Director, The Japanese Society of Gastroenterology (JSGE)
  • Director, The Japanese Society of Molecular Medicine
  • Councilor, The Japanese Cancer Association
  • Councilor, The Japanese Association for Infectious Diseases
Editorial Boards
  • Journal of Hepatology Associate Editor
  • Hepatology Editorial Board
  • Journal of Gastroenterology (Official journal of JSGE), Deputy Editor-in-Chief
  • Hepatology Research (Official journal of JSH), Deputy Editor-in-Chief
Honors
1999 Oda Award, The Japan Society of Hepatology
2000 Bälz Award

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