1.    Furuta J, Umebayashi Y, Miyamoto K, Kikuchi K, Otsuka F, Sugiura T, Ushijima T: Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci 95: 962-968, 2004

2.    Ihn H: Pathogenesis of scleroderma: The role of autocrine TGF-β signaling.　Connective Tissue 36: 209-216, 2004.

3.    Sato-Takeda M, Ihn H, Ohashi J, Tsuchiya N, Satake M, Arita H, Tamaki K, Hanaoka K, Tokunaga K, Yabe T: The human histocompatibility leukocyte antigen (HLA) haplotype is associated with the onset of postherpetic neuralgia after herpes zoster. Pain 110: 329-336, 2004.

4.    Furukawa H, Nakamura K, Zheng X, Tojo M, Oyama N, Akiba H, Nishibu A, Kaneko F, Tsunemi Y, Saeki H, Tamaki K: Enhanced TARC production by dust-mite allergens and its modulation by immunosuppressive drugs in PBMCs from patients with atopic dermatitis. J Dermatol Sci 35: 35-42, 2004.

5.    Chen H-C, Kadono T, Mimura Y, Saeki H, Tamaki K: High-frequency ultrasound as a useful device in the preliminary differentiation of lichen sclerosus et atrophicus from morphea. J Dermatol 31: 556-559, 2004.

6.    Mizutani K, Tamada Y, Matsumoto Y, Hara K, Tsuzuki T, Saeki H, Tamaki K: Imatinib Masylate inhibits the growth of matastatic lung lesions in a patient with dermatofibrosarcoma protuberans. Br J Dermatol 151: 235-237, 2004.

7.    Watanabe T, Murakami T, Okochi H, Kikuchi K, Furue M: Int J Dermatol 43: 472-473, 2004.

8.    Ohtsuka R, Sudo N, Sekiyama M, Watanabe C, Inaoka T, Kadono T: Gender difference in daily time and space use among Bangladeshi villagers under arsenic hazard: application of the compact spot-check method. J Biosoc Sci 36:317-332,2004.

9.    Fujimoto M, Hamaguchi Y, Yazawa N, Komura K, Takehara K, Sato S: Autoantibodies to a collagen-specific molecular chaperone, heat-shock protein 47, in systemic sclerosis. Clin Exp Immunol 138: 534-539, 2004.

10.    Poe JC, Fujimoto Y, Hasegawa M, Hass KM, Sanford I, Bock CB, Fujimoto M, Tedder TF: CD22 regulates B lymphocyte function in vivo through both ligand-dependent and -independent mechanisms.  Nature Immunol 5: 1078-1087, 2004

11.    Shirasawa S, Sugiyama S, Baba I, Inokuchi J, Sekine S, Ogino K, Kawamura Y, Dohi T, Fujimoto M, Sasazuki T: Loss of epiregulin results in dermatitis through dysregulation of immune-related responses. Proc Natl Acad Sci USA 101: 13921-13926, 2004

12.    Sato S, Fujimoto M, Hasegawa M, Takehara K: Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells. Arthritis Rheum 50: 1918-1927, 2004

13.    Tsuchiya N, Kuroki K, Fujimoto M, Murakami Y, Tedder TF, Tokunaga K, Takehara K, Sato S: Association of Functional CD19 Polymorphism with Susceptibility to Systemic Sclerosis (Scleroderma) Arthritis Rheum 50: 4002-4007, 2004

14.    Kawase, Y, Yanagi Y, Takato T, Fujimoto M, Okochi H: Characterization of multipotent adult stem cells from the skin: Transforming growth factor-β (TGF-β) facilitates cell growth. Exp Cell Res 295: 194-203, 2004

15.    Poe JC, Haas KM, Uchida J, Lee Y, Fujimoto M, Tedder TF: Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. J Immunol 172: 2100-2110, 2004

16.    Komura K, Sato S, Hasegawa M, Fujimoto M, Takehara K: Elevated circulating CD40L concentrations in patients with systemic sclerosis. J Rheumatol 31: 514-519, 2004

17.    Sato S, Fujimoto M, Hasegawa M, Komura K, Yanaba K, Hayakawa I, Matsushita T, Takehara K: Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis.  Rheumatology (Oxford) 43:1261-1266, 2004

18.    Sato S, Kodera M, Hasegawa M, Fujimoto M, Takehara K: Antinucleosome antibody is a major autoantibody in localized scleroderma.  Br J Dermatol 151:1182-1188, 2004

19.    Sugaya M, Lore K, Koup RA, Douek DC, Blauvelt A: HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters. J Immunol 172: 2219-2224, 2004.

20.    Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL: Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest 113: 701-718, 2004

21.    Kawamura T, Bruse SE, Abraha A, Sugaya M, Hartley O, Offord RE, Arts EJ, Zimmerman PA, Blauvelt A: PSC-RANTES blocks R5 human immunodeficiency virus infection of Langerhans cells isolated from individuals with a variety of CCR5 diplotypes. J Virol 78: 7602-7609, 2004

22.    Tada Y, Asahina A, Fujita H, Mitsui H, Torii H, Watanabe T, Tamaki K: Differential effects of LPS and TGF-beta on the production of IL-6 and IL-12 by Langerhans cells, splenic dendritic cells, and macrophages. Cytokine 25: 155-161, 2004

23.    Riedl E, Tada Y, Udey MC: Identification and characterization of an alternatively spliced isoform of mouse Langerin/CD207. J Invest Dermatol 123:78-86, 2004.

24.    Yano S, Komine M, Fujimoto M, Okochi H, Tamaki K: Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes. J Invest Dermatol 122: 783-790, 2004.

25.    Mitsui H, Watanabe T, Jinnin M, Kadono T, Idezuki T, Tamaki K: Mucinous carcinoma of the skin could have either an eccrine or an apocrine origin. Br J Dermatol 151: 1285-1286, 2004.

26.    Mitsui H, Watanabe T, Saeki H, Mori K, Fujita H, Tada Y, Asahina A, Nakamura K, Tamaki K: Differential expression and function of Toll-like receptors in Langerhans cells: comparison with splenic dendritic cells. J Invest Dermatol 122: 95-102, 2004.

27.    Michibata H, Chiba H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y: Identification and characterization of a novel component of the cornified envelope, cornifelin. Biochem Biophys Res Commun 318: 803-813, 2004.

28.    Chiba H, Michibata H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y: Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin. J Biol Chem 279: 12890-12897, 2004.
 
29.    Asano Y, Ihn H, Yamane K, Jinnin M, Mimura Y, Tamaki K: Phosphatidylinositol 3-kinase is involved in α2(I) collagen gene expression in normal and scleroderma fibroblasts. J Immunol 172: 7123-7135, 2004.

30.    Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K: Increased expression levels of integrin avb5 on scleroderma fibroblasts. Am J Pathol 164: 1275-1292, 2004.

31.    Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K: Impaired Smad7-Smurf-mediated negative regulation of TGF-β signaling in scleroderma fibroblasts. J Clin Invest 113: 253-264, 2004.

32.    Asano Y, Ihn H, Shikada J, Kadono T, Kikuchi K, Tamaki K: Br J Dermatol 150:1213-1214, 2004.

33.    Asano N, Fujimoto M, Yazawa N, Shirasawa S, Hasegawa M, Okochi H, Tamaki K, Tedder TF, Sato S: B lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. Am J Pathol 165: 641-650, 2004.

34.    Fujita H, Asahina A, Gao P, Fujiwara H, Tamaki K: Expression and regulation of RANTES/CCL5, MIP-1a/CCL3, and MIP-1b/CCL4 in mouse Langerhans cells. J Invest Dermatol 122: 1331-1333, 2004

35.    Fujita H, Asahina A, Mitsui H, Tamaki K: Langerhans cells exhibit low responsiveness to double-stranded RNA. Biochem Biophys Res Com 319: 832-839, 2004

36.    Tsunemi Y, Ihn H, Saeki H, Tamaki K: The lesional skin of linear IgA bullous dermatosis expresses growth-regulated peptide (GRO)-alpha. J Dermatol 31: 546-551, 2004.

37.    Tsunemi Y, Komine M, Sekiya T, Saeki H, Nakamura K, Hirai K, Kakinuma T, Kagami S, Fujita H, Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K: The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients.　Exp Dermatol 13: 715-719, 2004.

38.    Tsunemi Y, Tada Y, Saeki H, Ihn H, Tamaki K: Clin Exp Dermatol 29: 483-485, 2004.

39.    Tsunemi Y, Sekiya T, Saeki H, Hirai K, Ohta K, Nakamura K, Kakinuma T, Fujita H, Kagami S, Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K: Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients. Acta Derm Venereol 84: 187-190, 2004.

40.    Furukawa H, Nakamura K, Zheng X, Tojo M, Oyama N, Akiba H, Nishibu A, Kaneko F, Tsunemi Y, Saeki H, Tamaki K: Enhanced TARC production by dust-mite allergens and its modulation by immunosuppressive drugs in PBMCs from patients with atopic dermatitis. J Dermatol Sci 35: 35-42, 2004.

41.    Tsunemi Y, Ihn H, Saeki H, Tamaki K: J Dermatol 31: 142-5, 2004.

42.    Tsunemi Y, Saeki H, Ihn H, Tamaki K: Dermatology 208: 229-30, 2004.

43.    Tsunemi Y, Tada Y, Saeki H, Ihn H, Tamaki K: Clin Exp Dermatol 29: 483-485, 2004.

44.    Jinnin M, Ihn H, Asano Y, Yamane K, Trojanowska M, Tamaki K: Tenascin-C upregulation by transforming growth factor-b in human dermal fibroblasts involves Smad3, Sp1 and Ets-1. Oncogene 23: 1656-1667, 2004.

45.    Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K: Serum levels of manganese superoxidase dismutase in patients withl localized scleroderma. Exp Dermatol 13: 357-360, 2004.

46.    Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Serum matrix metaloproteinase-3 in systemic sclerosis. Arch Dermatol Res 296: 25-29, 2004.

47.    Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Serum levels of tissue inhibitor of metalloproteinase-1 and 2 in patients with eosinophilic faciitis. Br J Dermatol 151: 407-412, 2004.

48.    Jinnin M, Ihn H, Yamane K, Tamaki K: Interleukin-13 stimulates the transcription of the human a2(I) collagen gene in human dermal fibroblasts. J Biol Chem 279: 41783-41791, 2004.

49.    Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Yazawa N, Tamaki K: Rheumatoid factor isotypes and anti-agalactosyl IgG antibodies in systemic sclerosis. Br J Dermatol 151:803-808, 2004.
 
50.    Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K: Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway. J Invest Dermatol 122:1390-1398, 2004.

51.    Sasaki K. Sugaya M. Fujita H. Takeuchi K. Torii H. Asahina A. Tamaki K.  Br J Dermatol 150:1202-7, 2004.