〜著書・論文〜
1. Kikuchi K, Kubo M, Hoashi T, Tamaki K: Decreased MMP-9 activity in the
serum of patients with diffuse cutaneous systemic sclerosis. Clin Exp Dermatol
27: 310-315, 2002.
2. Soma Y, Mizoguchi M, Yamane K, Yazawa N, Kubo M, Ihn H, Kikuchi K, Tamaki
K: Specific inhibition of human skin fibroblast chemotaxis to platelet-derived
growth factor A-chain homodimer by transforming growth factor-b1. Arch Dermatol
Res 293: 609-613, 2002.
3. Lew W, Chang SK, Kwahck H, Tada Y, Nakamura K, Tamaki K: Serum monocyte
chemoattractant protein-1 is elevated in lepromatous leprosy patients with
high bacterial indices. Int J Lepr Other Mycobact Dis 70: 129-131, 2002.
4. Zheng X, Nakamura K, Tojo M, Oyama N, Nishibu A, Satoh M, Kakinuma T,
Wakugawa M, Tamaki K, Kaneko F: TGF-beta (1)-mediated regulation of thymus
and activation-regulated chemokine (TARC/CCL17) synthesis and secretion
by HaCaT cells co-stimulated with TNF-alpha and IFN-gamma. J Dermatol Sci
30: 154-160, 2002.
5. Komine M, Nishina H, Ohtsuki M, Nakagawa H, Tamaki K: Effects of vitamin
D3 analogues on the immunomodulatory function of keratinocytes and lymphocytes.
Tsambaos D, Merk H Eds: Modern Trends in Skin Pharmacology. Athens: Parissianos
Medical Publications; p. 67-74, 2002.
6. Seiffert K, Hosoi J, Torii H, Ozawa H, Ding W, Campton K, Wagner JA,
Granstein RD: Catecholamines inhibit the antigen-presenting capability of
epidermal Langerhans cells. J Immunol 168: 6128-6135, 2002.
7. Ihn H: The role of TGF-b signaling in the pathogenesis of fibrosis in
scleroderma. Arch Immunol Ther Exp 50: 325-331, 2002.
8. Ihn H: Pathogenesis of fibrosis: role of TGF-b and CTGF. Curr Opin Rheumatol
14: 681-685, 2002.
9. Ihn H, Yamane K, Asano Y, Kubo M, Tamaki K: Interleukin-4 up-regulates
the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts
via the p38 mitogen-activated protein kinase-dependent pathway. J Immunol
168: 1895-1902, 2002.
10. Ihn H, Tamaki K: Mitogenic activity of dermatofibrosarcoma protuberans
is mediated via an extracellular signal related kinase dependent pathway.
J Invest Dermatol 119: 954-960, 2002.
11. Ihn H, Asano Y, Kubo M, Yamane K, Jinnin M, Yazawa N, Fujimoto M, Tamaki
K: Clinical significance of serum surfactant protein D (SP-D) in patients
with polymyositis/dermatomyositis: correlation with interstitial lung disease.
Rheumatology 41: 1268-1272, 2002.
12. Saeki H, Hattori N, Mitsui H, Adachi M, Imakado S, Ishibashi Y, Tamaki
K: J Dermatol 29: 168-171, 2002.
13. Saeki H, Asano N, Tsunemi Y, Takekoshi T, Kishimoto M, Mitsui H, Tada
Y, Torii H, Komine M, Asahina A, Tamaki K: Polymorphisms of vitamin D receptor
gene in Japanese patients with psoriasis vulgaris. J Dermatol Sci 30: 167-171,
2002.
14. Watanabe T, Kawamura T, Jacob SE, Aquilino EA, Orenstein JM, Black
JB, Blauvelt A: Pityriasis rosea is associated with systemic active infection
with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol
119: 793-797, 2002.
15. Wakugawa M, Nakamura K, Kakinuma T, Tamaki K: CC chemokine receptor
4 as a possible target for therapy of atopic dermatitis. Drug News Perspect
15: 175-179, 2002.
16. Kadono T, Inaoka T, Murayama N, Ushijima K, Nagano M, Nakamura S, Watanabe
C, Tamaki K, Ohtsuka R: Skin manifestations of arsenicosis in two villages
of Bangladesh. Int J Dermatol 41: 841-846, 2002.
17. Kadono T, Venturi GM, Steeber DA, Tedder TF: Leukocyte rolling velocities
and migration are optimized by cooperative L-selectin and intercellular
adhesion molecule-1 functions. J Immunol 169: 4542-4550, 2002.
18. Hamaguchi Y, Nishizawa Y, Yasui M, Hasegawa M, Kaburagi Y, Komura K,
Nagaoka T, Saito E, Shimada Y, Takehara K, Kadono T, Steeber DA, Tedder
TF, Sato S: Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced
lung fibrosis. Am J Pathol 161: 1607-1618, 2002.
19. Kaburagi Y, Hasegawa M, Nagaoka T, Shimada Y, Hamaguchi Y, Komura K,
Saito E, Yanaba K, Takehara K, Kadono T, Steeber DA, Tedder TF, Sato S:
The cutaneous reverse Arthus reaction requires intercellular adhesion molecule
1 and L-selectin expression. J Immunol 168: 2970-2978, 2002.
20. Tu L, Poe JC, Kadono T, Venturi GM, Bullard DC, Tedder TF, Steeber
DA: A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial
cell interactions in vivo. J Immunol 169: 2034-2043, 2002.
21. Hattori N, Komine M, Yano S, Kaneko T, Hanakawa Y, Hashimoto K, Tamaki
K: Interferon-g, a strong suppressor of cell proliferation, induces upregulation
of keratin 6, one of the inflammatory- and proliferation-associated keratins.
J Invest Dermatol 119: 403-410, 2002.
22. Fujimoto M, Poe JC, Satterthwaite AB, Wahl MI, Witte ON, Tedder TF:
Complementary roles for CD19 and Bruton’s tyrosine kinase in B lymphocyte
signal transduction. J Immunol 168: 5465-5476, 2002.
23. Kubo M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Prevalence of
52-kDa and 60-kDa Ro/SS-A autoantibodies in Japanese patients with polymyositis/dermatomyositis.
J Am Acad Dermatol 47: 148-151, 2002.
24. Kubo M, Ihn H, Yamane K, Tamaki K: Up-regulated expression of transforming
growth factor b receptors in dermal fibroblasts of the skin sections from
patients with systemic sclerosis. J Rheumatol 29: 2558-2564, 2002.
25. Kubo M, Ihn H, Kuwana M, Asano Y, Tamaki T, Yamane K, Tamaki K: Anti-U5
snRNP antibody as a possible serological marker for scleroderma-polymyositis
overlap. Rheumatology 41: 531-534, 2002.
26. Nagaoka Y, Asahina A, Yano S, Tamaki K: Acta Derm Venereol 82: 219-220,
2002.
27. Nagaoka Y, Nakamura K, Yasaka N, Watanabe T, Asahina A, Tamaki K: Identification
and characterization of the low-affinity receptor for immunoglobulin E (FcepsilonRII/CD23)
on murine Langerhans cells. J Invest Dermatol 119: 130-136, 2002.
28. Kakinuma T, Nakamura K, Wakugawa M, Mitsui H, Tada Y, Saeki H, Torii
H, Komine M, Asahina A, Tamaki K: Serum macrophage-derived chemokine (MDC)
levels are closely related with the disease activity of atopic dermatitis.
Clin Exp Immunol 127: 270-273, 2002.
29. Kakinuma T, Nakamura K, Wakugawa M, Yano S, Saeki H, Torii H, Komine
M, Asahina A, Tamaki K: IL-4, but not IL-13, modulates TARC (thymus and
activation-regulated chemokine)/CCL17 and IP-10 (interferon-induced protein
of 10kDa)/CXCL10 release by TNFa and IFNg in HaCaT cell line. Cytokine 20:
1-6, 2002.
30. Sugaya M, Nakamura K, Watanabe T, Asahina A, Yasaka N, Koyama Y, Kusubata
M, Ushiki Y, Kimura K, Morooka A, Irie S, Yokoyama T, Inoue K, Itohara S,
Tamaki K: Expression of cellular prion-related protein by murine Langerhans
cells and keratinocytes. J Dermatol Sci 28: 126-134, 2002.
31. Yano S, Nakamura K, Okochi H, Tamaki K: Analysis of the expression
of cutaneous lymphocyte-associated antigen on the peripheral blood and cutaneous
lymphocytes of alopecia areata patients. Acta Derm Venereol 82: 82-85, 2002.
32. Ito Y, Arai S, van Oers NS, Aifantis I, von Boehmer H, Miyazaki T:
Positive selection by the pre-TCR yields mature CD8+ T cells. J Immunol
169: 4913-4919, 2002.
33. Mitsui H, Komine M, Watanabe T, Kikuchi K, Okochi H, Tamaki K: Br J
Dermatol 146: 908-911, 2002.
34. Yamane K, Ihn H, Kubo M, Tamaki K: Increased transcriptional activities
of transforming growth factor-b receptors in scleroderma fibroblasts. Arthritis
Rheum 46: 2421-2428, 2002.
35. Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Br J Dermatol
146: 1084-1086, 2002.
36. Jinnin M, Ihn H, Asano Y, Yamane K, Yazawa N, Tamaki K: Autoimmune
response to 52-kDa and 60-kDa Ro/SS-A antigens in mixed connective tissue
disease. Br J Dermatol 147: 827-829, 2002.
37. Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K: Serum levels
of tissue inhibitor of metalloproteinases in patients with mixed connective
tissue disease. Clin Exp Rheumatol 20: 539-542, 2002.
38. Tsunemi Y, Hattori N, Saeki H, Adachi M, Komine M, Nakagawa H, Tamaki
K: J Dermatol 29: 768-772, 2002.
39. Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Fujita H, Asano
N, Kishimoto M, Tanida Y, Kakinuma T, Mitsui H, Tada Y, Wakugawa M, Torii
H, Komine M, Asahina A, Tamaki K: Interleukin-12 p40 gene (IL12B) 3'-untranslated
region polymorphism is associated with susceptibility to atopic dermatitis
and psoriasis vulgaris. J Dermatol Sci 30: 161-166, 2002.
40. Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Kakinuma T, Fujita
H, Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K: Interleukin-13 gene
polymorphism G4257A is associated with atopic dermatitis in Japanese patients.
J Dermatol Sci 30: 100-107, 2002.
41. Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Fujita H, Asano
N, Tanida Y, Kakinuma T, Wakugawa M, Torii H, Tamaki K: Eotaxin gene single
nucleotide polymorphisms in the promoter and exon regions are not associated
with susceptibility to atopic dermatitis, but two of them in the promoter
region are associated with serum IgE levels in patients with atopic dermatitis.
J Dermatol Sci 29: 222-228, 2002.
〜外来症例〜
(i)患者数
|
新来
|
延数
|
一日平均
|
| 1月 |
221 |
3975 |
209.2 |
| 2月 |
198 |
3826 |
191.3 |
| 3月 |
255 |
4027 |
201.4 |
| 4月 |
278 |
4263 |
203.0 |
| 5月 |
339 |
4493 |
214.0 |
| 6月 |
262 |
4146 |
207.3 |
| 7月 |
321 |
4654 |
202.3 |
| 8月 |
298 |
4284 |
194.7 |
| 9月 |
213 |
3748 |
197.3 |
| 10月 |
257 |
4244 |
192.9 |
| 11月 |
225 |
3973 |
198.7 |
| 12月 |
201 |
3850 |
202.6 |
| 合計 |
3068 |
49483 |
|
(ii) 初診病名
| 湿疹・皮膚炎 |
1128 |
色素異常症 |
83 |
| 蕁麻疹 |
151 |
肉芽腫症 |
12 |
| 中毒疹 |
53 |
スピロヘーター・原虫・動物 |
34 |
| 膠原病 |
48 |
紅斑症 |
34 |
| 水疱症 |
10 |
毛髪疾患 |
67 |
| 血管炎 |
12 |
物理的・化学的障害 |
60 |
| 細菌感染症 |
134 |
皮膚潰瘍・壊疽 |
22 |
| 真菌感染症 |
245 |
紫斑 |
20 |
| ウイルス感染症 |
240 |
良性腫瘍 |
473 |
| 炎症性角化症 |
109 |
悪性腫瘍 |
58 |
| 膿疱症 |
23 |
母斑・母斑症 |
199 |
| 角化症 |
34 |
その他 |
283 |
| 毛嚢脂腺系 |
174 |
|
|
| 合計 |
3706
(他科入院中の皮膚科初診患者を含む)
|
〜入院症例〜
(i) 患者数
|
新入院
|
延数
|
一日平均
|
実病床数
|
稼動率(%) |
| 1月 |
35 |
840 |
27.1 |
24 |
112.9 |
| 2月 |
24 |
876 |
31.3 |
24 |
130.4 |
| 3月 |
33 |
1028 |
33.2 |
24 |
138.2 |
| 4月 |
37 |
955 |
31.8 |
24 |
132.6 |
| 5月 |
35 |
834 |
26.9 |
24 |
112.1 |
| 6月 |
31 |
719 |
24.0 |
24 |
99.9 |
| 7月 |
43 |
853 |
27.5 |
24 |
114.7 |
| 8月 |
42 |
976 |
31.5 |
24 |
131.2 |
| 9月 |
25 |
811 |
27.0 |
24 |
112.6 |
| 10月 |
42 |
833 |
26.9 |
24 |
112.0 |
| 11月 |
42 |
1126 |
37.5 |
24 |
156.4 |
| 12月 |
35 |
1046 |
33.7 |
24 |
140.6 |
| 合計 |
424 |
10897 |
|
|
|
(ii) 病名
| 症例 |
男性 |
女性 |
合計 |
|
| 湿疹・皮膚炎 |
18 |
7 |
25 |
(内19例がアトピー性皮膚炎) |
| 良性腫瘍 |
18 |
12 |
30 |
|
| 悪性腫瘍 |
43 |
51 |
94 |
|
| 感染症 |
39 |
32 |
71 |
(内35例が帯状疱疹) |
| 母斑・母斑症 |
13 |
16 |
29 |
(内9例が色素性母斑) |
| 紅斑症 |
3 |
6 |
9 |
|
| 物理的・化学的障害 |
5 |
9 |
14 |
|
| 角化症・炎症性角化症 |
16 |
10 |
26 |
(内25例が乾癬) |
| 膠原病 |
10 |
78 |
88 |
(内54例が汎発性強皮症) |
| 血管炎・血行障害 |
0 |
3 |
3 |
|
| 中毒疹 |
8 |
5 |
13 |
|
| 紫斑 |
0 |
2 |
2 |
|
| 白斑 |
2 |
0 |
2 |
|
| 水疱症 |
5 |
3 |
8 |
|
| 肉芽腫症 |
5 |
0 |
5 |
|
| 毛髪疾患 |
0 |
1 |
1 |
|
| 合計 |
185 |
235 |
420 |
|
〜手術症例〜
(i-a) 手術件数 (中央手術室)
|
件数
|
一週平均
|
| 1月 |
8 |
2.0 |
| 2月 |
9 |
2.3 |
| 3月 |
5 |
1.7 |
| 4月 |
9 |
1.3 |
| 5月 |
9 |
1.8 |
| 6月 |
5 |
1.3 |
| 7月 |
6 |
1.5 |
| 8月 |
14 |
2.8 |
| 9月 |
7 |
1.8 |
| 10月 |
9 |
1.8 |
| 11月 |
6 |
1.5 |
| 12月 |
9 |
2.3 |
| 合計 |
96 (レーザー照射16例を含む) |
1.8 |
(i-b) 手術症例 (中央手術室)
| 皮膚悪性腫瘍 |
40 |
| ページェット病 |
3 |
| 悪性黒色腫 |
9 |
| 基底細胞癌 |
8 |
| 有棘細胞癌 |
8 |
| ボーエン病 |
5 |
| 隆起性皮膚線維肉腫 |
2 |
| その他 |
5 |
| 皮膚良性腫瘍 |
20 |
| レーザー照射 |
16 |
| その他 |
20 |
合計
(レーザー照射16例を含む) |
96 |
(ii-a) 手術件数 (外来手術室)
|
件数
|
一週平均
|
| 1月 |
67 |
15.2 |
| 2月 |
72 |
18.0 |
| 3月 |
76 |
17.3 |
| 4月 |
104 |
24.2 |
| 5月 |
79 |
18.0 |
| 6月 |
71 |
16.5 |
| 7月 |
71 |
16.1 |
| 8月 |
70 |
15.9 |
| 9月 |
55 |
12.8 |
| 10月 |
73 |
16.6 |
| 11月 |
89 |
20.6 |
| 12月 |
80 |
18.2 |
| 合計 |
907 |
17.5 |
(ii-b) 手術症例 (外来手術室)
| 生検 |
419 |
| 皮膚良性腫瘍 |
430 |
| 粉瘤 |
128 |
| 色素性母斑 |
122 |
| 皮膚線維腫 |
28 |
| その他 |
152 |
| 皮膚悪性腫瘍 |
48 |
| 日光角化症 |
14 |
| 基底細胞癌 |
11 |
| ボーエン病 |
13 |
| 有棘細胞癌 |
5 |
| その他 |
5 |
| 陥入爪 |
13 |
| その他 |
31 |
| 合計 |
941 |
〜レーザー症例〜
(i) レーザー照射件数
|
DYE
|
ALEX
|
CO2
|
合計
|
| 1月 |
19 |
13 |
3 |
35 |
| 2月 |
24 |
7 |
1 |
32 |
| 3月 |
23 |
20 |
1 |
44 |
| 4月 |
16 |
10 |
3 |
29 |
| 5月 |
22 |
20 |
6 |
48 |
| 6月 |
17 |
14 |
5 |
36 |
| 7月 |
29 |
13 |
3 |
45 |
| 8月 |
24 |
21 |
5 |
50 |
| 9月 |
24 |
20 |
1 |
45 |
| 10月 |
33 |
14 |
8 |
55 |
| 11月 |
25 |
15 |
4 |
44 |
| 12月 |
25 |
26 |
2 |
53 |
| 合計 |
281 |
193 |
42 |
516 |
(iI) レーザー照射症例
| DYEレーザー |
| 単純性血管腫 |
208 |
| 苺状血管腫 |
55 |
| 毛細血管拡張・酒さ |
12 |
| その他 |
6 |
| 合計 |
281 |
| ALEXレーザー |
| 太田母斑 |
64 |
| 扁平母斑・ベッカー母斑 |
48 |
| 青色母斑・異所性蒙古斑 |
16 |
| 外傷性刺青 |
8 |
| 老人性色素斑 |
42 |
| 色素性母斑 |
10 |
| その他 |
5 |
| 合計 |
193 |
| CO2レーザー |
| 汗管腫 |
14 |
| 尋常性疣贅 |
5 |
| 色素性母斑 |
2 |
| 黄色腫 |
2 |
| その他 |
19 |
| 合計 |
42 |